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文献

  1. Wagner H, Horhammer L, Munster R. The chemistry of silymarin (silybin), the active principle of the fruits of Silybum marianum (L.) Gaertn. Arzneim-Forsch Drug Res 1968;18:688–96.
  2. Hikino H, Kiso Y, Wagner H, Fiebig M. Antihepatotoxic actions of flavonolignans from Silybum marianum fruits. Planta Medica 1984;50:248–50.
  3. Faulstich H, Jahn W, Wieland T. Silibinin inhibition of amatoxin uptake in the perfused rat liver. Arzneim-Forsch Drug Res 1980;30:452–4.
  4. Tuchweber B, Sieck R, Trost W. Prevention by silibinin of phalloidin induced hepatotoxicity. Toxicol Appl Pharmacol 1979;51:265–75.
  5. Feher J, Lang I, Deak G, et al. Free radicals in tissue damage in liver diseases and therapeutic approach. Tokai J Exp Clin Med 1986;11:121–34.
  6. Sonnenbichler J, Zetl I. Stimulating influence of a flavonolignan derivative on proliferation, RNA synthesis and protein synthesis in liver cells. In Assessment and Management of Hepatobiliary Disease, ed. L Okolicsanyi, G Csomos, G Crepaldi. Berlin: Springer-Verlag, 1987, 265–72.
  7. Schuppan D, Strösser W, Burkard G, Walosek G. Legalon® lessens fibrosing activity in patients with chronic liver diseases. Zeits Allgemeinmed 1998;74:577–84.
  8. Salmi HA, Sama S. Effect of silymarin on chemical, functional and morphological alterations of the liver. Scand J Gastroenterol 1982;17:517–21.
  9. Leng-Peschlow E. Alcohol-related liver diseases-use of Legalon®. Z Klin Med 1994;2:22–7.
  10. Ferenci P, Dragosics B, Dittrich H, et al. Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver. J Hepatol 1989;9:105–13.
  11. Velussi M, Cernogoi AM, De Monte A, et al. Long-term (12 months) treatment with an antioxidant drug (silymarin) is effective on hyperinsulinemia, exogenous insulin need and malondialdehyde levels in cirrhotic diabetic patients. J Hepatology 1997;26:871–9.
  12. Pares A, Plancs R, Torres M, et al. Effects of silymarin in alcoholic patients with cirrhosis of the liver: results of a controlled, double-blind, randomized and multicenter trial. J Hepatol 1998;28:615–21.
  13. Nassuato G, Iemmolo RM, Strazzabosco M, et al. Effect of silibinin on biliary lipid composition. Experimental and clinical study. J Hepatol 1991;12:290–5.
  14. Palasciano G, Portinascasa P, Palmieri V, et al. The effect of silymarin on plasma levels of malondialdehyde in patients receiving long-term treatment with psychotropic drugs. Curr Ther Res 1994;S5:S37–45.
  15. Allain H, Schück S, Lebreton S, et al. Aminotransferase levels and silymarin in de novo tacrine-treated patients with Alzheimer’s disease. Dementia Geriatr Cogn Disorders 1999;10:181–5.
  16. Brown DJ. Herbal Prescriptions for Better Health. Rocklin, CA: Prima Publishing, 1996, 151–8.
  17. Reyes H. The spectrum of liver and gastrointestinal disease seen in cholestasis of pregnancy. Gastroert Clin N Am 1992;21:905–21.
  18. Adverse Drug Reactions Advisory Committee. An adverse reaction to the herbal medication milk thistle (Silybum marianum). MJA 1999;170:218–9.

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植物性健康食品

  • 葉や茎を利用した成分
  • 穀物・胚芽・種子を利用した成分
  • 花粉・花・果実を利用した成分
    • 花粉
    • サフラン
    • 紅花
    • 白桃花
    • 梅
    • プルーン
    • ベリー
    • パパイア
    • ノニ
    • メロン
    • ザクロ
    • 羅漢果
    • 山査子
    • 夕顔
    • 枸杞
    • ガルシニア・カンボジア
    • サージ
    • フラボノイド
    • ミルクティスル
    • ジュニパー(セイヨウネズ)
    • カモミール
  • 根・地下茎・鱗茎を利用した成分
  • 樹皮・樹木を利用した成分
  • ハーブ
  • 植物皮脂
  • 健康酢
  • 植物酵素
  • 藻類

動物性健康食品

  • 蜜蜂・ローヤルゼリー類
  • 動物エキス類
  • 軟骨・骨髄類
  • 動物酵素
  • 魚介エキス類
  • 卵・乳類
  • コンドロイチン
  • グルコサミン

ビタミン及びミネラル

  • ビタミン
  • ミネラル
  • アミノ酸
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